Anti-TIAM1 [4E7b] Antibody
![Anti-TIAM1 [4E7b] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1679_2001202001265716780.jpg "Anti-TIAM1 [4E7b] Antibody")
This mouse monoclonal antibody was raised against recombinant T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and recognizes human, mouse and rat TIAM1.
Highlights:
- Reacts with human, mouse and rat TIAM1
- Suitable for Western Blot and Immunoprecipitation applications
T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome.
From the laboratories of The Antibody Technology Resource and Jihong Bai, PhD, Fred Hutchinson Cancer Research Center.
This mouse monoclonal antibody was raised against recombinant T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and recognizes human, mouse and rat TIAM1.
Highlights:
- Reacts with human, mouse and rat TIAM1
- Suitable for Western Blot and Immunoprecipitation applications
T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome.
From the laboratories of The Antibody Technology Resource and Jihong Bai, PhD, Fred Hutchinson Cancer Research Center.
| Product Type: | Antibody |
| Antigen: | TIAM1 |
| Accession ID: | Q13009, NP_001002255.1 |
| Molecular Weight: | 178 kDa |
| Clonality: | Monoclonal |
| Clone Name: | 4E7b |
| Reactivity: | Human, Mouse and Rat |
| Immunogen: | Recombinant TIAM1 GEF domain (mouse 1029-1418) |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB (1:1000), IP |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell. 2018 Jun 18;45(6):738-752.e6. doi: 10.1016/j.devcel.2018.05.021. PubMed PMID: 29920278.
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