Morphinan N-demethylase (MND)
Morphinan N-demethylase (MND), isolated from novel strain of Methylobacterium and produced recombinantly in E. coli.
Morphinan N-demethylase (MND) is a versatile morphinan N-demethylase isolated from a novel strain of Methylobacterium that is able to N-demethylate a broad substrate range with varying efficiencies but converts morphinan substrates such as morphine, thebaine and codeine most efficiently. Other compound classes N-demethylated by MND including benzylisoquinoline, galanthamine, and tropane alkaloids.
From the laboratory of Toni M. Kutchan, PhD and Megan Augustin, Donald Danforth Plant Science Center.
Morphinan N-demethylase (MND), isolated from novel strain of Methylobacterium and produced recombinantly in E. coli.
Morphinan N-demethylase (MND) is a versatile morphinan N-demethylase isolated from a novel strain of Methylobacterium that is able to N-demethylate a broad substrate range with varying efficiencies but converts morphinan substrates such as morphine, thebaine and codeine most efficiently. Other compound classes N-demethylated by MND including benzylisoquinoline, galanthamine, and tropane alkaloids.
From the laboratory of Toni M. Kutchan, PhD and Megan Augustin, Donald Danforth Plant Science Center.
Specifications
| Product Type: | Protein |
| Name: | Morphinan N-demethylase (MND) |
| Source: | Isolated from a novel strain of Methylobacterium and produced in E. coli |
| Molecular Weight: | 74,237 Da |
| Fusion Tag(s): | HIS |
| Purity: | Purified using HIS tag |
| Buffer: | 50 mM potassium phosphate pH 8.0/ 10% glycerol |
| Concentration: | ~0.5 mg/mL *Protein concentration provided does not include the GroEL protein. |
| Comments: | Morphinan N-demethylase (MND) is produced in E. coli cells along with the GroEL/GroES chaperone proteins and purified using His-tag. GroEL is co-purified with MND. Protein concentration provided does not include the GroEL protein. |
| Storage: | -80C |
| Shipped: | Dry Ice |
Data
SDS-PAGE
Provider
From the laboratory of Toni M. Kutchan, PhD and Megan Augustin, Donald Danforth Plant Science Center.
References
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