Anti-IL-21R (CD360) [4A9] Antibody
![Anti-IL-21R (CD360) [4A9] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1832_2001202001270318310.jpg "Anti-IL-21R (CD360) [4A9] Antibody")
This rat IgG2a monoclonal antibody was raised against rat YB2/0 cell line expressing truncated IL-2R and is specific for mouse Interleukin 21 receptor (IL-21R).
Highlights:
- Reacts with mouse IL-21R
- Antibody has been shown to block the biological activity of IL-21R in vivo
IL-21 receptor (IL-21R) also known as CD360, is a member of the type 1 cytokine receptor family that forms a functional heterodimeric receptor complex with the common gamma chain (CD132). IL-21R is expressed on both resting and activated B cells, T cells, NK cells and dendritic cells. Upon IL-21 binding, IL-21R activates downstream Jak-1, Jak-3, STAT1, STAT3 and STAT 5 signal transduction pathways to induce the proliferation and differentiation of T lymphocytes, B lymphocytes, and NK cells.
From the laboratory of Thomas R. Malek, PhD, University of Miami.
This rat IgG2a monoclonal antibody was raised against rat YB2/0 cell line expressing truncated IL-2R and is specific for mouse Interleukin 21 receptor (IL-21R).
Highlights:
- Reacts with mouse IL-21R
- Antibody has been shown to block the biological activity of IL-21R in vivo
IL-21 receptor (IL-21R) also known as CD360, is a member of the type 1 cytokine receptor family that forms a functional heterodimeric receptor complex with the common gamma chain (CD132). IL-21R is expressed on both resting and activated B cells, T cells, NK cells and dendritic cells. Upon IL-21 binding, IL-21R activates downstream Jak-1, Jak-3, STAT1, STAT3 and STAT 5 signal transduction pathways to induce the proliferation and differentiation of T lymphocytes, B lymphocytes, and NK cells.
From the laboratory of Thomas R. Malek, PhD, University of Miami.
| Product Type: | Antibody |
| Antigen: | IL-21R |
| Accession ID: | Q9HBE5 |
| Molecular Weight: | 41-53kDa |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 4A9 |
| Reactivity: | Mouse |
| Species Immunized: | Lewis Rat |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol. 2004 Jul 1;173(1):657-65. PubMed PMID: 15210829.
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