Anti-Caspase 12 [14F7] Antibody
This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 12.
Caspase 12, an enzyme encoded by the CASP12 gene, is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Once a stimulus is received by the cell, discrete apoptotic pathways are potentiated by subsets of the caspases that can then activate additional intracellular effectors. Caspase 12 is involved in apoptosis induced by ER stress.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 12.
Caspase 12, an enzyme encoded by the CASP12 gene, is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Once a stimulus is received by the cell, discrete apoptotic pathways are potentiated by subsets of the caspases that can then activate additional intracellular effectors. Caspase 12 is involved in apoptosis induced by ER stress.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Antibody |
| Name: | Anti-Caspase 12 (14F7) |
| Accession ID: | Q6UXS9 |
| Host: | Rat |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 14F7 |
| Specificity: | Caspase 12 (mouse) |
| Immunogen: | Bacterial fusion protein (p30) |
| Format: | Liquid |
| Purification Method: | Protein G affinity purified |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA, IHC, IP |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
Provider
From a laboratory at Harvard University.
References
- Juying Li. Et al. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology, Vol 9, Number3, March 2007
- Toshiyuki Nakagawa et al. Cross-talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis. JCB, Vol 150, Number 4, August 21, 2000
- Toshiyuki Nakagawa et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-ß. Nature, Vol 403, 2 January 2000
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