Anti-WWOX [12G5] Antibody
WW domain containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a WW domain containing oxidoreductase protein which contains two WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this protein is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this protein in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
WW domain containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a WW domain containing oxidoreductase protein which contains two WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this protein is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this protein in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Name: | Anti-WWOX (12G5) |
| Accession ID: | Q9NZC7 |
| Host: | Rat |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | 12G5 |
| Specificity: | WWOX |
| Immunogen: | Bacterial fusion protein |
| Format: | Liquid |
| Purification Method: | Protein G affinity purified |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
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