Human α-Synuclein, A53T Variant (α-syn-A53T)

Alpha-synuclein A53T variant.

Alpha-synuclein (α-synuclein) is an intrinsically disordered protein of unknown function that is linked to both familial and sporadic cases of Parkinson's disease, where it forms the major constituent of the pathological Lewy body aggregates. Certain cases of early-onset familial Parkinson's disease have been connected to the A53T α-synuclein variant; therefore, this peptide can be used for binding studies as well as for modelling Parkinson's via the generation of fibrils, which have been shown to seed endogenous α-synuclein inclusions in healthy cells.

From the laboratory of Scott D. Ryan, PhD, University of Guelph.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EGP013
Human α-Synuclein, A53T Variant (α-syn-A53T)
1mg In stock
Regular Price:$260.00
On Sale:
Specifications

Product Type: Protein
Name: recombinant human _-synuclein mutant A53T variant
Alternative Name(s): alpha-syn-A53T
Accession ID: P37840
Source: Human, expressed in E. coli BL21 (DE3) CP+
Molecular Weight: 14,490.10
Amino Acid Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQL GKNEEGAPQEGILEDMPVDP
Fusion Tag(s): None
Purity: >95 %, purified by ion-exchange chromatography followed by reverse phase chromatography
Buffer: 10mM KPB pH 7.4
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Scott D. Ryan, PhD, University of Guelph.
References
  1. Ryan, T., Bamm, V.V., Stykel, M.G., Coackley, C.L., Humphries, K.M., Jamieson-Williams, R., Ambasudhan, R., Mosser, D.D., Lipton, S.A., Harauz, G., et al. (2018). Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat. Commun 9, 1-17. doi:10.1038/s41467-018-03241-9.
  2. Stykel, M.G., Humphries, K., Kirby, M.P., Czaniecki, C., Wang, T., Ryan, T., Bamm, V., Ryan, S.D. (2018). Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinsons disease. Faseb. J 32, 5350-5364. doi:10.1096/fj.201700759RR.

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