FVBN Macrophage Cell Line
Macrophage cell line isolated from bone marrow in FVBN mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
FVBN mice are also referred to as Friend Virus B NIH Jackson, FVBN are a widely used multipurpose inbred strain and can reproduce a larger litter size. These mice are used for transgenic injection and are homozygous for the retinal degeneration 1 allele of Pde6brd1, resulting in blindness by wean age.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
Macrophage cell line isolated from bone marrow in FVBN mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
FVBN mice are also referred to as Friend Virus B NIH Jackson, FVBN are a widely used multipurpose inbred strain and can reproduce a larger litter size. These mice are used for transgenic injection and are homozygous for the retinal degeneration 1 allele of Pde6brd1, resulting in blindness by wean age.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
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Specifications
| Product Type: | Cell Line |
| Name: | FVB/N |
| Cell Type: | Macrophage |
| Morphology: | Adherent |
| Organism: | Mouse |
| Source: | Bone Marrow |
| Biosafety Level: | BSL2 |
| Growth Conditions: | DMEM + 10% FBS + Glutamine |
| Cryopreservation: | 90% FBS + 10% DMSO |
| Storage: | Liquid Nitrogen |
| Shipped: | Dry Ice |
Provider
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
Comments
The line is not producing any murine Type C retroviruses as it was derived with a replication defective packaging cell line.
References
- Blasi E, Radzioch D, Merletti L, Varesio L. Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer Biochem Biophys. 1989;10(4):303-317.
- Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature. 1985;318(6047):667-670.
- Xiao C, Wang RH, Lahusen TJ, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012;287(50):41903-41913.
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