LAT/LAB KO (C57) Macrophage Cell Line
A knockout linker for activation of T cells (LAT)/linker for activation of B cells (LAB) macrophage cell line isolated from spleen in C57BL/6 mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
LAT (linker for activation of T cells) plays an important role in the positive and negative regulation of lymphocyte maturation, activation, and differentiation. LAB (linker for activation of B cells), also called NTAL, is necessary to fine-tune lymphocyte activation and may be a key regulator of innate immune responses.C57BL/6 also known as C57 black 6, C57 or black 6, is a common inbred strain of laboratory mouse. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
A knockout linker for activation of T cells (LAT)/linker for activation of B cells (LAB) macrophage cell line isolated from spleen in C57BL/6 mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
LAT (linker for activation of T cells) plays an important role in the positive and negative regulation of lymphocyte maturation, activation, and differentiation. LAB (linker for activation of B cells), also called NTAL, is necessary to fine-tune lymphocyte activation and may be a key regulator of innate immune responses.C57BL/6 also known as C57 black 6, C57 or black 6, is a common inbred strain of laboratory mouse. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
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| Product Type: | Cell Line |
| Name: | LAT/LAB KO (C57) |
| Cell Type: | Macrophage |
| Morphology: | Adherent |
| Organism: | Mouse |
| Source: | Spleen |
| Biosafety Level: | BSL2 |
| Growth Conditions: | DMEM + 10% FBS + Glutamine |
| Cryopreservation: | 90% FBS + 10% DMSO |
| Storage: | Liquid Nitrogen |
| Shipped: | Dry Ice |
- Blasi E, Radzioch D, Merletti L, Varesio L. Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer Biochem Biophys. 1989;10(4):303-317.
- Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature. 1985;318(6047):667-670.
- Xiao C, Wang RH, Lahusen TJ, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012;287(50):41903-41913.
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