STAT6 KO (BalbC) Macrophage Cell Line
A knockout signal transducer and activator of transcription 6 (STAT6) macrophage cell line isolated from bone marrow in BALBC mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. BALB/c mice are useful for research into both cancer and immunology.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
A knockout signal transducer and activator of transcription 6 (STAT6) macrophage cell line isolated from bone marrow in BALBC mice after immortalization with a retrovirus (J2) containing the myc and v-raf oncogenes.
All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. BALB/c mice are useful for research into both cancer and immunology.
From the laboratory of Howard A. Young, PhD, National Cancer Institute/NIH.
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| Product Type: | Cell Line |
| Name: | STAT6 KO (BalbC) |
| Cell Type: | Macrophage |
| Accession ID: | P42226 |
| Morphology: | Adherent |
| Organism: | Mouse |
| Source: | Bone Marrow |
| Biosafety Level: | BSL2 |
| Growth Conditions: | DMEM + 10% FBS + Glutamine |
| Cryopreservation: | 90% FBS + 10% DMSO |
| Storage: | Liquid Nitrogen |
| Shipped: | Dry Ice |
- Blasi E, Radzioch D, Merletti L, Varesio L. Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer Biochem Biophys. 1989;10(4):303-317.
- Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature. 1985;318(6047):667-670.
- Xiao C, Wang RH, Lahusen TJ, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012;287(50):41903-41913.
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