Anti-TNFSF13/APRIL [A3D8] Antibody
![Anti-TNFSF13/APRIL [A3D8] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-TNFSF13/APRIL [A3D8] Antibody")
This armenian hamster monoclonal antibody, TNFSF13/APRIL, was raised against Maltose binding protein (MBP) fusion of mouse soluble APRIL. Although the epitope is not known, the antibody stains APRIL - transfected cells.
Highlights:
- The antibody stains APRIL-transfected cells
- Suitable for flow cytometry, ELISA (reported in literature) applications
Tumor necrosis factor ligand superfamily member 13 (TNFSF13), also known as APRIL (A proliferation-inducing ligand), is a protein coding gene and a member of the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF17/BCMA, also interacts with TNFRSF13B/TACI. It was reported to be expressed in high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues, and specifically in monocytes and macrophages. TNFSF13 is found to be important for B cell development. It plays a role in regulation of tumor cell growth and is associated with diseases such as Brain Glioblastoma Multiforme and Rheumatoid Arthritis. The clinical relevance of this protein has also shown to be as a potential target for autoimmune diseases and B cell malignancies.
From the laboratory of Eckhard R. Podack, MD, PhD , University of Miami.
This armenian hamster monoclonal antibody, TNFSF13/APRIL, was raised against Maltose binding protein (MBP) fusion of mouse soluble APRIL. Although the epitope is not known, the antibody stains APRIL - transfected cells.
Highlights:
- The antibody stains APRIL-transfected cells
- Suitable for flow cytometry, ELISA (reported in literature) applications
Tumor necrosis factor ligand superfamily member 13 (TNFSF13), also known as APRIL (A proliferation-inducing ligand), is a protein coding gene and a member of the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF17/BCMA, also interacts with TNFRSF13B/TACI. It was reported to be expressed in high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues, and specifically in monocytes and macrophages. TNFSF13 is found to be important for B cell development. It plays a role in regulation of tumor cell growth and is associated with diseases such as Brain Glioblastoma Multiforme and Rheumatoid Arthritis. The clinical relevance of this protein has also shown to be as a potential target for autoimmune diseases and B cell malignancies.
From the laboratory of Eckhard R. Podack, MD, PhD , University of Miami.
| Product Type: | Antibody |
| Name: | Anti-TNFSF13/APRIL [A3D8] Antibody |
| Alternative Name(s): | TNF Superfamily Member 13; APRIL; TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2); TNF-related death ligand 1 (TRDL-1); CD256 |
| Antigen: | TNFSF13 |
| Accession ID: | O75888, NP_076006, Q9D777 |
| Molecular Weight: | 26.89kDa (calculated) |
| Isotype: | IgG1, k (according to BD isotyping Abs) |
| Clonality: | Monoclonal |
| Clone Name: | A3D8 |
| Reactivity: | Human and mouse |
| Specificity: | Detects TNFSF13/APRIL in APRIL transfected cells. |
| Immunogen: | Maltose binding protein (MBP) fusion of mouse soluble APRIL |
| Species Immunized: | Armenian hamster |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | Flow Cytometry, ELISA (reported in literature) |
| Concentration: | 1mg/mL |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Xiao Y, Motomura S, Deyev V, Podack ER. TNF superfamily member 13, APRIL, inhibits allergic lung inflammation. Eur J Immunol. 2011 Jan;41(1):164-71. doi: 10.1002/eji.201040436. Epub 2010 Dec 1. PMID: 21182087; PMCID: PMC3516998.
- Xiao Y, Motomura S, Podack ER. APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur J Immunol. 2008 Dec;38(12):3450-8. doi: 10.1002/eji.200838640. PMID: 19016524; PMCID: PMC2755626.
- Pollok K, Mothes R, Ulbricht C, Liebheit A, Gerken JD, Uhlmann S, Paul F, Niesner R, Radbruch H, Hauser AE. The chronically inflamed central nervous system provides niches for long-lived plasma cells. Acta Neuropathol Commun. 2017 Nov 25;5(1):88. doi: 10.1186/s40478-017-0487-8. PMID: 29178933; PMCID: PMC5702095.
- Sindhava VJ, Scholz JL, Stohl W, Cancro MP. APRIL mediates peritoneal B-1 cell homeostasis. Immunol Lett. 2014 Aug;160(2):120-7. doi: 10.1016/j.imlet.2014.01.018. Epub 2014 Feb 7. PMID: 24512739; PMCID: PMC4058418.
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