Anti-pp60src [GD11] Antibody
![Anti-pp60src [GD11] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-pp60src [GD11] Antibody")
This IgG1 monoclonal antibody was generated against recombinant chicken pp60Src and recognizes human, mouse, rat, mink, and avian pp60Src.
Highlights:
- Reacts with human, mouse, rat, mink, and avian pp60Src
- May be useful for oncogenic studies
- Suitable for Western Blot, Immunoprecipitation applications
Src kinase family is a family of non-receptor tyrosine kinases that includes eight members, with all of them having similar domain structure. Src is one such member, and this protein coding gene may play a role in the regulation of embryonic development and cell growth. The transforming protein of Rous sarcoma virus, pp60src, has an enzymatic activity of a protein kinase and the ability to phosphorylate tyrosine in protein substrates.(2) It encodes the viral src gene that attributes to oncogenesis by the avian sarcoma virus.(3)
From a laboratory at University of Virginia.
This IgG1 monoclonal antibody was generated against recombinant chicken pp60Src and recognizes human, mouse, rat, mink, and avian pp60Src.
Highlights:
- Reacts with human, mouse, rat, mink, and avian pp60Src
- May be useful for oncogenic studies
- Suitable for Western Blot, Immunoprecipitation applications
Src kinase family is a family of non-receptor tyrosine kinases that includes eight members, with all of them having similar domain structure. Src is one such member, and this protein coding gene may play a role in the regulation of embryonic development and cell growth. The transforming protein of Rous sarcoma virus, pp60src, has an enzymatic activity of a protein kinase and the ability to phosphorylate tyrosine in protein substrates.(2) It encodes the viral src gene that attributes to oncogenesis by the avian sarcoma virus.(3)
From a laboratory at University of Virginia.
| Product Type: | Antibody |
| Name: | Anti-pp60src [GD11] Antibody |
| Antigen: | pp60src |
| Accession ID: | Q71UK5 |
| Molecular Weight: | 60kDa |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | GD11 |
| Reactivity: | Mink, rat, human, mouse, avian |
| Immunogen: | Recombinant chicken pp60src; v-src |
| Species Immunized: | Mouse |
| Epitope: | Amino acids 82-169 |
| Buffer: | PBS, 0.05% Sodium Azide |
| Tested Applications: | WB, IP, IPK |
| Storage: | -20C |
| Shipped: | Cold packs |
- Parsons SJ, McCarley DJ, Ely CM, Benjamin DC, Parsons JT. Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin. J Virol. 1984 Aug;51(2):272-82. doi: 10.1128/JVI.51.2.272-282.1984. PMID: 6205164; PMCID: PMC254436.
- Levinson AD, Courtneidge SA, Bishop JM. Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). Proc Natl Acad Sci U S A. 1981 Mar;78(3):1624-8. doi: 10.1073/pnas.78.3.1624. PMID: 6262821; PMCID: PMC319184.
- Courtneidge SA, Levinson AD, Bishop JM. The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3783-7. doi: 10.1073/pnas.77.7.3783. PMID: 6253989; PMCID: PMC349710.
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