Anti-OxPL [10C12] Antibody
This mouse IgM Kappa monoclonal antibody was generated from spleens of ApoE KO mice fed a high-fat Western diet (for 7 months), and is specific to oxidized phospholipids POVPC and PGPC.
Highlights:
- Reacts with oxidized phospholipids POVPC and PGPC
- Suitable for Immunohistochemistry and ELISA applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 10C12
Phospholipids are a crucial component of all cell membranes. They are composed of a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue. Their application can be found to be very useful in nanotechnology and material science, as purified phospholipids can be produced commercially. Oxidized phospholipids (such as the derivatives POVPC and PGPC) play an important role in cardiovascular diseases, as well as inflammation.
From a laboratory at University of Virginia.
This mouse IgM Kappa monoclonal antibody was generated from spleens of ApoE KO mice fed a high-fat Western diet (for 7 months), and is specific to oxidized phospholipids POVPC and PGPC.
Highlights:
- Reacts with oxidized phospholipids POVPC and PGPC
- Suitable for Immunohistochemistry and ELISA applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 10C12
Phospholipids are a crucial component of all cell membranes. They are composed of a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue. Their application can be found to be very useful in nanotechnology and material science, as purified phospholipids can be produced commercially. Oxidized phospholipids (such as the derivatives POVPC and PGPC) play an important role in cardiovascular diseases, as well as inflammation.
From a laboratory at University of Virginia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-OxPL [10C12] Antibody |
| Antigen: | OxPL |
| Isotype: |
EG1050: IgM Kappa (mouse) Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | 10C12 |
| Immunogen: | POVPC/PGPC (OxPL) |
| Species Immunized: | Mouse |
| Purification Method: | Protein A or A/G affinity purified |
| Buffer: |
EG1050: PBS with 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | IHC, ELISA |
| Storage: | -20C |
| Shipped: | Cold packs |
- Cherepanova OA, Owens GK. Abstract 622: Development of an antioxidized phospholipid neutralizing antibody as an atheroprotective therapeutic agent. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(suppl_1).
- Cherepanova OA, Srikakulapu P, Greene ES, Chaklader M, Haskins RM, McCanna ME, Bandyopadhyay S, Ban B, Leitinger N, McNamara CA, Owens GK. Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):206-219. doi: 10.1161/ATVBAHA.119.312771. Epub 2019 Oct 24. PMID: 31645128; PMCID: PMC7006879.
If you publish research with this product, please let us know so we can cite your paper.
