Goat Anti-FOXL2 / BPES Antibody
This goat IgG polyclonal antibody was generated against peptide sequence C-DSKTGALHSRLDL from the C Terminus of forkhead box L2 (FOXL2/BPES) and recognizes human FOXL2/BPES.
Highlights:
- Reacts with human FOXL2/BPES
- Suitable for Peptide ELISA and Western Blot applications
- Mutations are associated with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II and premature ovarian failure
Forkhead box L2 (FOXL2/BPES) is a forkhead transcription factor that contains a fork-head DNA-binding domain. FOXL2 is preferentially expressed in the ovaries, the eyelids, and the pituitary gland. Studies indicate FOXL2 plays a role in all stages of ovarian development and function as well as granulosa cell-related diseases. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II and premature ovarian failure.
This goat IgG polyclonal antibody was generated against peptide sequence C-DSKTGALHSRLDL from the C Terminus of forkhead box L2 (FOXL2/BPES) and recognizes human FOXL2/BPES.
Highlights:
- Reacts with human FOXL2/BPES
- Suitable for Peptide ELISA and Western Blot applications
- Mutations are associated with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II and premature ovarian failure
Forkhead box L2 (FOXL2/BPES) is a forkhead transcription factor that contains a fork-head DNA-binding domain. FOXL2 is preferentially expressed in the ovaries, the eyelids, and the pituitary gland. Studies indicate FOXL2 plays a role in all stages of ovarian development and function as well as granulosa cell-related diseases. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II and premature ovarian failure.
| Product Type: | Antibody |
| Name: | Goat Anti-FOXL2 / BPES Antibody |
| Alternative Name(s): | BPES, PFRK, POF3, BPES1, PINTO |
| Accession ID: | NP_075555.1 |
| Antigen: | FOXL2 / BPES |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Human |
| Specificity: | FOXL2 / BPES |
| Immunogen: | CDSKTGALHSRLDL |
| Species Immunized: | Goat |
| Epitope: | C Terminus |
| Purification Method: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide |
| Buffer: | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Tested Applications: | Pep-ELISA, WB |
| Storage: | Aliquot and store at -20C. Minimize freezing and thawing. |
| Shipped: | Cold Packs |
Western Blot and Immunohistochemistry
I. (1µg/ml) staining of Mouse Ovary lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. II. (8µg/ml) staining of paraffin embedded Human Ovary. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining. III. Negative control showing staining of paraffin embedded Human Ovary with no primary antibody.
- Padua MB, Fox SC, Jiang T, Morse DA, Tevosian SG., Simultaneous Gene Deletion of Gata4 and Gata6 Leads to Early Disruption of Follicular Development and Germ Cell Loss in the Murine Ovary., Biol Reprod. 2014 Jun 4. ,24899573
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