Anti-Flavivirus E Protein [D1-4G2-4-15] Antibody
This mouse IgG2a monoclonal antibody was generated against flavivirus envelope proteins and recognizes the domain II of protein E (fusion loop) of flavivirus.
Highlights:
- Recognizes Dengue virus, West Nile Virus, Japanese Encephalitis and Zika virus
- Suitable for Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 4G2
The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.
This mouse IgG2a monoclonal antibody was generated against flavivirus envelope proteins and recognizes the domain II of protein E (fusion loop) of flavivirus.
Highlights:
- Recognizes Dengue virus, West Nile Virus, Japanese Encephalitis and Zika virus
- Suitable for Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 4G2
The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Flavivirus E Protein [D1-4G2-4-15] Antibody |
| Antigen: | Flavivirus Envelope (E) Protein |
| Isotype: |
FCG001: IgG2a kappa Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | D1-4G2-4-15 |
| Reactivity: | Virus |
| Specificity: | Virus |
| Immunogen: | Flavivirus envelope proteins |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: |
FCG001:PBS, pH 7.2 Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | IF |
| Storage: | Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C. |
| Shipped: | Cold packs |
Detection of ZIKV via immunofluorescence
Sample confocal images of forebrain-specific hNPCs 56 hr after infection with ZIKV supernatant, immunostained for ZIKV envelop protein (ZIKVE; green) and DAPI (gray). Cells were differentiated from the C1-2 hiPSC line. Scale bars, 20 ?m.
Adapted from: Tang H, et al. Cell Stem Cell. 2016 May 5;18(5):587-90.
- Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H, Ming GL. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016 May 5;18(5):587-90.
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