Anti-AMIGO2 [30G9.1G2] Antibody
![Anti-AMIGO2 [30G9.1G2] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1346_2001202001264413450.jpg "Anti-AMIGO2 [30G9.1G2] Antibody")
This mouse monoclonal antibody was generated against a mammalian expressed cohesin-hAMIGO2 fusion protein and recognizes human Amphoterin-induced protein 2 (AMIGO2).
Highlights:
- Specific for human AMIGO2
- Suitable for ELISA, FACS, and Immunohistochemistry applications
Amphoterin-induced protein 2 (AMIGO2), also known as Alivin1, contains Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. It belongs to the immunoglobulin superfamily, AMIGO family. AMIGO2 is required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. AMIGO2 may contribute to signal transduction through its intracellular domain. AMIGO2 may be required for tumorigenesis of a subset of gastric adenocarcinomas.
From the laboratory of Gerard Zurawski, PhD, Baylor Scott & White Research Institute.
This mouse monoclonal antibody was generated against a mammalian expressed cohesin-hAMIGO2 fusion protein and recognizes human Amphoterin-induced protein 2 (AMIGO2).
Highlights:
- Specific for human AMIGO2
- Suitable for ELISA, FACS, and Immunohistochemistry applications
Amphoterin-induced protein 2 (AMIGO2), also known as Alivin1, contains Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. It belongs to the immunoglobulin superfamily, AMIGO family. AMIGO2 is required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. AMIGO2 may contribute to signal transduction through its intracellular domain. AMIGO2 may be required for tumorigenesis of a subset of gastric adenocarcinomas.
From the laboratory of Gerard Zurawski, PhD, Baylor Scott & White Research Institute.
| Product Type: | Antibody |
| Antigen: | cohesin-Amigo2 Ecto domain |
| Accession ID: | NP_862830 |
| Molecular Weight: | 60,374 Da (fusion protein) Ecto domain of Amigo2 (40-397) |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | AB60_71.30G9.1G2 |
| Reactivity: | Human |
| Immunogen: | Mammalian expressed C-terminal fusion protein. N-terminal HisTag-cohesin-hAmigo2 (residues 40-397) |
| Species Immunized: | mouse BalbC (myeloma fusion with SP2-0/Ag14) |
| Purification Method: | MabSelect (ProA Affinity) |
| Buffer: | PBS (MgCa++) |
| Tested Applications: | ELISA, FACS, IHC |
| Storage: | Long term -80C; Short term 4C; avoid freeze thaws |
| Shipped: | Cold packs |
Immunohistochemistry
Immunohistochemistry of paraffin-embedded skin utilizing Anti-hAMIGO2 30G9.1G2. (A) Representative images of IHC performed on paraffin-embeded skin. (B) Isotype control shows clear contrast to actual staining pattern with AMIGO2 antibody.
FACS
(A) Anti-hAMIGO2 30G9.1G2 on CHO cells stably expressing full length AMIGO2. (B) Anti-hAMIGO2 30G9.1G2 on CHO cells. Purified Mabs stained at 2 ug/ml; 500000 cells/pt, Secondary staining with 1:250 goat anti-mouse IgG PE (BD Biosciences); PBS 2% BSA staining buffer used.
- Lin LL, Kost ER, Lin CL, Valente P, Wang CM, Kolonin MG, Daquinag AC, Tan X, Lucio N, Hung CN, Wang CP, Kirma NB, Huang TH. PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. Cell Rep. 2020 Oct 13;33(2):108253. View Article
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