This mouse monoclonal Anti-Hepatitis Delta Virus (HDV) antibody was raised against Hepatitis Delta Antigen (HDAg). The two antibody clones, FD3A7 & FD5C4, were screened to ensure pan-genotypic specificity.
Highlights:
Chronic Hepatitis Delta Virus (HDV) infections represent the most severe form of viral hepatitis with about 20 million infected individuals worldwide. HDV is a satellite virus of Hepatitis B Virus (HBV), which means that all patients chronically infected with HDV are always co-infected with HBV. There are 8 different HDV genotypes described worldwide. The HDV genome encodes for only one protein: the Hepatitis Delta Antigen (HDAg).
From the laboratory of Stephan Urban, PhD , Heidelberg University.
Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
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Product Type: | Antibody |
Name: | Anti-Hepatitis Delta Virus (HDV), Pan-Genotypic [FD3A7] Antibody |
Accession ID: | Synthetic, chimeric sequence (consensus of all 8 genotypes). Most similarity (93%) with Genbank SCC98289 |
Antigen: | Hepatitis Delta Antigen (HDAg) |
Molecular Weight: | 25kD |
Isotype: | IgG1 kappa (FD3A7) and IgG2b kappa (FD5C4) |
Clonality: | Monoclonal |
Clone Name: | FD3A7 and FD5C4 |
Reactivity: | Virus (Hepatitis Delta Virus) |
Immunogen: | Full-length protein |
Species Immunized: | Mouse, BALB/c |
Buffer: | Cell culture supernatant |
Tested Applications: | WB, IF 1:100 (may be optimized further if needed) |
Storage: | -80C (Avoid multiple freeze/thaw cycles) |
Shipped: | Cold Packs |
(A) Western blot. Lysates of cells expressing HDAg of different genotypes was separated by SDSPAGE, blotted and incubated with the mAb FD3A7 at 1:500 dilution. (B) Immunofluorescence. HuH7 cells were transfected with plasmids encoding HDAg of different HDV genotypes. Cells were fixed, permeabilized and incubated with the two mAb clones at 1:20-500 dilution. A goatanti-mouse-Alexa545 antibody was used for detection. Both mAb clones detect HDAg of all HDV genotypes.
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