Anti-RAGE, V Domain [2A11] Antibody
This mouse IgG1 monoclonal antibody [2A11] is specific for the V-domain of human advanced glycosylation end product-specific receptor (AGER, RAGE).
Highlights:
- Inhibits activation of RAGE by blocking the V-domain
- Recognizes both glycosolated and unglycosolated forms
- Suitable for Western Blot , Immunohistochemistry, Immunofluorescence, ELISA and Flow Cytometry applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 2E11.
Advanced glycosylation end product-specific receptor (AGER, RAGE) mediates interactions of advanced glycosylation end products (AGE), nonenzymatically glycosylated proteins. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. RAGE acts as a receptor for amyloid beta peptide and contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane in cortical neurons. The V domain binds multiple ligands that elicit sustained inflammation associated with diabetes, cancer, Alzheimer’s, multiple sclerosis, and other diseases.
From the laboratory of Estelle Leclerc, PhD, North Dakota State University.
This mouse IgG1 monoclonal antibody [2A11] is specific for the V-domain of human advanced glycosylation end product-specific receptor (AGER, RAGE).
Highlights:
- Inhibits activation of RAGE by blocking the V-domain
- Recognizes both glycosolated and unglycosolated forms
- Suitable for Western Blot , Immunohistochemistry, Immunofluorescence, ELISA and Flow Cytometry applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 2E11.
Advanced glycosylation end product-specific receptor (AGER, RAGE) mediates interactions of advanced glycosylation end products (AGE), nonenzymatically glycosylated proteins. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. RAGE acts as a receptor for amyloid beta peptide and contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane in cortical neurons. The V domain binds multiple ligands that elicit sustained inflammation associated with diabetes, cancer, Alzheimer’s, multiple sclerosis, and other diseases.
From the laboratory of Estelle Leclerc, PhD, North Dakota State University.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | RAGE, V Domain [2A11] Antibody |
| Antigen: | Advanced glycosylation end product-specific receptor (AGER, RAGE) |
| Accession ID: | Q15109 |
| Molecular Weight: | 42.8 kDa |
| Isotype: |
ENS001: IgG1 Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | 2A11 |
| Reactivity: | Human (others not tested) |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: |
ENS001: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | WB, IHC (1-5ug/mL), IF (1ug/mL), Flow Cytometry (1ug/mL), ELISA (1ug/mL); Has not been tested on parafin-embedded sections |
| Storage: | -20C |
| Shipped: | Cold packs |
If you publish research with this product, please let us know so we can cite your paper.
