Anti-MHC Class I H2 Kk [AF3-12.1.3] Antibody
This mouse IgG1 monoclonal antibody was generated against H-2Kk, and recognizes mouse H2Kk MHC Class I.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AF3-12.1.3.
MHC Class I H-2 Kk is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.
From a laboratory at University of Chicago.
This mouse IgG1 monoclonal antibody was generated against H-2Kk, and recognizes mouse H2Kk MHC Class I.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AF3-12.1.3.
MHC Class I H-2 Kk is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.
From a laboratory at University of Chicago.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Mouse H-2Kk MHC Class I (AF3-12.1.3) |
| Accession ID: | P04223, A0A0B4J1G3 |
| Host: | Mouse |
| Isotype: |
EZ1001: IgG1 Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | AF3-12.1.3 |
| Specificity: | This antibody recognizes mouse H-2Kk MHC Class I |
| Immunogen: | H-2Kk |
| Format: | Liquid |
| Purification Method: | Protein G purified |
| Buffer: |
EZ1001: PBS with 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | Immunofluorescence, flow cytometry |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
- Burrows, G.G., et al. Variation in H-2Kk Peptide Motif Revealed by Sequencing Naturally Processed Peptides Form T-Cell Hybridoma Class I Molecules. Journal of Neuroscience Research. 45: 803 - 811. 1996.
If you publish research with this product, please let us know so we can cite your paper.
