Anti-IMP Dehydrogenase [1D6-3E] Antibody
This mouse IgG1 monoclonal antibody recognizes human, rat and hamster inosine-5'-monophosphate (IMP) dehydrogenase.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 1D6-3E.
The enzyme inosine-5'-monophosphate (IMP) dehydrogenase is responsible for the rate-limiting step in guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis.
IMP dehydrogenase catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Because it is up-regulated in rapidly proliferating cells, human IMP dehydrogenase is actively targeted for immunosuppressive, anticancer, and antiviral chemotherapy.
From a laboratory at University of Chicago.
This mouse IgG1 monoclonal antibody recognizes human, rat and hamster inosine-5'-monophosphate (IMP) dehydrogenase.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 1D6-3E.
The enzyme inosine-5'-monophosphate (IMP) dehydrogenase is responsible for the rate-limiting step in guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis.
IMP dehydrogenase catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Because it is up-regulated in rapidly proliferating cells, human IMP dehydrogenase is actively targeted for immunosuppressive, anticancer, and antiviral chemotherapy.
From a laboratory at University of Chicago.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Inosine-5'-monophosphate Dehydrogenase (1D6-3E) |
| Accession ID: | P20839 |
| Host: | Mouse |
| Isotype: |
EZ2001: IgG1 Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | 1D6-3E |
| Specificity: | This antibody recognizes hamster, rat, and human forms |
| Format: | Liquid |
| Purification Method: | Protein G purified |
| Buffer: |
EZ2001: PBS with 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | Immunofluorescence, Western blot, ELISA |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
- Glesne, D.A., et al. Regulation of IMP Dehydrogenase Gene Expression by Its End Products, Guanine Nucleotides. Molecular and Cellular Biology. 11(11): 5417 - 5425. 1991.
If you publish research with this product, please let us know so we can cite your paper.
