Recombinant human S100A8/A9 heterodimer complex (Calprotectin) protein expressed in and purified from E. coli.
Highlights:
Calprotectin (CP), also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is a critical factor in the innate immune response to a wide range of microbial pathogens. CP functions in this role via a mechanism termed nutritional immunity, by sequestering essential transition metals required for growth and vitality. Recent literature has identified instances where over-accumulation of calprotectin can play a key role in inflammatory diseases, multiple forms of arthritis, tumor metastasis and sepsis. In the inflammatory response it has been shown that CP binding to extracellular receptors like pattern recognition proteins RAGE (Receptor for Advanced Glycation Endproducts) and Toll-like receptors (TLR) induce a positive feedback loop that promotes infection.
From the laboratory of Walter J. Chazin, PhD, Vanderbilt University.
Part of The Investigator's Annexe program.
Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
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Product Type: | Protein |
Name: | Calprotectin, MRP-8/MRP-14, S100A8/A9 |
Accession ID: | P05109, P06702, HS07074, HS08809 |
Source: | Recombinant (E. coli), bacterial overexpression |
Molecular Weight: | 23,945 Da |
Amino Acid Sequence: | MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETECPQYIRKKGADVWFKELDINTDGAVNFQEFLILVIKMGVAAHKKSHEESHKE/TCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP |
Purity: | >95%, endotoxin-free |
Buffer: | 20 mM Tris pH 8.0, 100 mM NaCl, 10 mM ?-mercaptoethanol |
Concentration: | 8.3mg/mL (EVU202, EVU204); 12.2mg/mL (EVU201, EVU203) |
Comments: | Quality control growth assays are performed on each batch of protein, ensuring that the protein is active |
Storage: | -80C |
Shipped: | Dry ice |
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