TFA-Amino modifier CPG 500
This high load, 500 controlled pore glass solid support is designed for the synthesis of oligonucleotides containing up to 50 bases with a 3'-amino group.
Amino group is protected with trifluoroacetyl (TFA) protection which is easily removed under standard deblock conditions.
The reagent is based on hydroxyprolinol core - a universal non-nucleoside structure that is naturally 100% chiral (no isomers formed upon condensation), and stable to all conditions of oligonucleotide synthesis and deblock.
This high load, 500 controlled pore glass solid support is designed for the synthesis of oligonucleotides containing up to 50 bases with a 3'-amino group.
Amino group is protected with trifluoroacetyl (TFA) protection which is easily removed under standard deblock conditions. The reagent is based on hydroxyprolinol core - a universal non-nucleoside structure that is naturally 100% chiral (no isomers formed upon condensation), and stable to all conditions of oligonucleotide synthesis and deblock.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
Specifications
| Product Type: | Small Molecule |
| Variant MPN: | 11860 |
| Format: | off-white beads |
| Purity: | NMR 1H and HPLC-MS (95%) of bound reagent, loading measurement |
| Comments: |
Oligo Synthesis Details: Pore size: 50 nm Typical loading, umol/g: 70-90 Coupling conditions: standard coupling, identical to normal nucleobases Cleavage conditions: ammonia, 2 h at room temperature Deprotection conditions: identical to protected nucleobases |
| Storage: | 24 months after receival at -20°C in the dark. |
| Shipped: | room temperature |
References
- Taskova, M.; Uhd, J.; Miotke, L.; Kubit, M.; Bell, J.; Ji, H.P.; Astakhova, K. Tandem Oligonucleotide Probe Annealing and Elongation To Discriminate Viral Sequence. Analytical Chemistry, 2017, 89(8), 4363Ð4366. doi: 10.1021/acs.analchem.7b00646
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