Influenza A H1N1 A/Brisbane/59/2007, Neuraminidase Antibodies
These mouse monoclonal antibodies (IgG2b) were raised against the NA of seasonal influenza A H1N1 virus A/Brisbane/59/2007.
Highlights:
- React with the NA of H1N1 (the 1918 pandemicH1N1, the seasonal H1N1 before 2009, and the 2009 pandemic H1N1) and H5N1 viruses
- Bind to a conserved NA (N1 subtype) epitopes containing residues 273, 338 and 339
- Suitable for ELISA, immunofluorescence assay and NA inhibition assay
- Can be used in NA potency assessment of influenza vaccines
Influenza A H1N1 virus has long been circulating in humans together with H3N2 and influenza B viruses, resulting in annual influenza epidemics. H1N1 virus contains two major surface glycoproteins haemagglutinin (HA) and neuraminidase (NA). HA is responsible for binding sialic acid receptors on host cells and the subsequent endocytosis and fusion, while NA facilitates the release of progeny virions from infected cells and thus plays an important role in the spread of influenza viruses. NA-specific immunity provides protection influenza, and NA is the major target of FDA-approved antivirals that are used in treating influenza.
From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.
These mouse monoclonal antibodies (IgG2b) were raised against the NA of seasonal influenza A H1N1 virus A/Brisbane/59/2007.
Highlights:
- React with the NA of H1N1 (the 1918 pandemicH1N1, the seasonal H1N1 before 2009, and the 2009 pandemic H1N1) and H5N1 viruses
- Bind to a conserved NA (N1 subtype) epitopes containing residues 273, 338 and 339
- Suitable for ELISA, immunofluorescence assay and NA inhibition assay
- Can be used in NA potency assessment of influenza vaccines
Influenza A H1N1 virus has long been circulating in humans together with H3N2 and influenza B viruses, resulting in annual influenza epidemics. H1N1 virus contains two major surface glycoproteins haemagglutinin (HA) and neuraminidase (NA). HA is responsible for binding sialic acid receptors on host cells and the subsequent endocytosis and fusion, while NA facilitates the release of progeny virions from infected cells and thus plays an important role in the spread of influenza viruses. NA-specific immunity provides protection influenza, and NA is the major target of FDA-approved antivirals that are used in treating influenza.
From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Accession ID: | P03470 |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | 1H5 or 4E9 |
| Reactivity: | Reacts with the NA of H1N1 (the 1918 pandemicH1N1, the seasonal H1N1 before 2009, and the 2009 pandemic H1N1) and H5N1 viruses |
| Immunogen: | Influenza A H1N1 A/Brisbane/59/2007 |
| Species Immunized: | Mouse |
| Epitope: | A highly conserved epitope containing residues 273, 338 and 339 of NA (N1 subtype). |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | ELISA, IF, ELLA (1H5 only) |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Hongquan W. Gao J. Xu K. Chen Hongjun. Couzens Lk. Rivers KH. Easterbrook JD. Yang K. Zhong L. Rajabi M. Jianqiang Y. Sultana I. Wan X, Liu X. Perez DR. Taubenberger JK. Eichelberger MC. Molecular Basis for Broad Neuraminidase Immunity: Conserved Epitopes in Seasonal and Pandemic H1N1 as Well as H5N1 Influenza Viruses. Journal of Virology. 2013 Aug 16;9290-9300
- Jiang L, Fantoni G, Couzens L, Gao J, Plant E, Ye Z, Eichelberger M, Wan H. Comparative Efficacy of Monoclonal Antibodies That Bind to Different Epitopes of the 2009 Pandemic H1N1 Influenza Virus Neuraminidase. Journal of Virology, 2016, 90(1): 117-128.
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