Xiaoping Du, MD, PhD, University of Illinois at Chicago

The Du laboratory studies thrombosis, hemostasis, and vascular biology. In particular, they are interested in the molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions. Blood platelets and vascular endothelial cells play critical roles in the development of atherosclerosis and thrombotic diseases (such as heart attack and stroke). Thus, understanding the mechanisms of platelet and endothelial cell functions at a molecular level would facilitate development of pharmacological agents useful in treating cardiovascular diseases.

The specific projects in their laboratory include the following: 1) Signaling and regulatory mechanisms of a platelet adhesion receptor, glycoprotein Ib-IX complex. The glycoprotein Ib-IX complex mediates initial platelet adhesion to injured vascular walls in arteries and capillaries. 2) The protein kinase signaling cascades leading to platelet activation, particularly, the activation of the platelet integrin alpha IIb/{beta} 3. Integrins mediate platelet adhesion, aggregation and formation of primary thrombi. 3) Regulatory mechanisms of integrins in platelets and endothelial cells.

Part of The Investigator's Annexe program.