Research in the Parker Laboratory focuses on using chemical biology and proteomics to develop biosensors for intracellular phosphorylation signaling. They use synthetic peptide and protein chemistry to design and synthesize probes for multiplexed analysis of cancer-related signaling proteins e.g. Abl, other Src-family kinases, receptor tyrosine kinases, etc. They are also exploring a wide variety of multidisciplinary analytical methods including mass spectrometry, fluorescence microscopy and flow cytometry to develop novel techniques for monitoring these signaling proteins and their activities.
Read Dr. Parker's blog post, Development of Photocleavable Alpha-Factor for Yeast »
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