The overall goal of research in the Lee Laboratory is to characterize the differences between antigenically naive (virgin) and memory T helper cells at the developmental, phenotypic, and functional levels. They have a particular interest in the study of the collaborative interaction between B and T lymphocytes which leads to immunoglobulin secretion ie. the ability of either virgin or memory T cells to promote the activation and differentiation of antigen-specific B cells. They are also actively studying the differential susceptibility of virgin and memory T cells to activation and tolerance signals, which has potential implication with respect to autoimmunity.
Part of The Investigator's Annexe program.