William S. Trimble, PhD, FRSC, Hospital for Sick Children
Dr. Trimble's lab is aimed at understanding the mechanisms that control the fusion of intracellular membranes. Such fusion events are responsible for everything from the secretion of neurotransmitters in the brain, the release of hormones into the bloodstream, the maintenance of organelle structure, cell division and a host of other biological processes.Specifically, his team are examining the SNARE proteins, which are thought to control the docking and fusion of secretory vesicles with the plasma membrane. Also, they are looking into the role of septins and SNAREs in cell division, to understand how they are regulated, to define their role in cytokinesis and to investigate their possible roles in aberrant cell division leading to cancer.
Part of The Investigator's Annexe program.
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References
- Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS. Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010 Nov 15;191(4):741-9.
- Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 2013 Oct 18;288(42):30075-86.
