Juliet M. Daniel, PhD, McMaster University
The Daniel lab's long term goal is focused on understanding the cellular and molecular basis of cadherin-mediated adhesion in normal cell growth, development and tumourigenesis. In human cancer, it is tumour metastases to vital organs such as the lungs and liver, and not the primary tumour itself that proves fatal. However, despite significant advances in our understanding of the underlying principles of tumour initiation, the mechanisms governing tumour progression from the benign to the malignant invasive phase remain poorly understood. Hence a thorough understanding of the factors that regulate and control cell adhesion and motility would significantly facilitate the development of improved cancer therapies.
Part of The Investigator's Annexe program.
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References
- Daniel JM, Spring CM, Reynolds AB, Crawford HC and Baig A. The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. (2002) Nucleic Acids Res. 30: 2911-2919.
- Kelly KF, Spring CM, Otchere AA and Daniel JM. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. (2004) J. Cell Sci. 117: 2675-2686
- Donaldson NS, Nordgaard CL, Pierre CC, Kelly KF, Robinson S, Swystun L, Henriquez R, Graham M and Daniel JM. Kaiso regulates Znf131-mediated transcriptional activation. (2010) Exp. Cell Res. 316:1692-1705
