John W. Steinke, PhD, Larry C. Borish, MD, and S. Brandon Early, University of Virginia

John W. Steinke, PhD
John W. Steinke, PhD
Larry C. Borish, MD
Larry C. Borish, MD

The Steinke lab group's research focuses on three main areas: (1) The molecular genetic studies in allergic disease and asthma, (2) The determination of the molecular mechanism of nasal polyp formation, and (3) Mechanism's of rhinovirus-induced asthma exacerbations.

The Borish lab group's research focuses on three main areas: (1) Determine the molecular mechanisms of AERD, (2) Mast cell function is chronic urticaria, and (3) Mechanism's of rhinovirus-induced asthma exacerbations.

The Investigator's Annexe Part of The Investigator's Annexe program.

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References

  1. Laidlaw, T.M., Steinke, J.W., Tiñana, A.M., Xing, W.,Lam, B.K., Paruchuri, S., Boyce, J.A., and Borish, L. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI. Journal of Allergy and Clinical Immunology 127:815-822.e5 (2011)
  2. Kirshenbaum AS, Akin C, Wu Y, Rottem M, Goff JP, Beaven MA, Rao K, Metcalfe DD Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRIα Leukemia Research 2003; 27: 677-682
  3. Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott, LM and Metcalfe DD Demonstration that human mast cells arise from a progenitor cell population that is CD34+, c-kit+, and expresses aminopeptidase N (CD13) Blood 1999; 94,7: 2333-2342