Peter Palese, PhD, Icahn School of Medicine at Mount Sinai

Peter Palese, PhD
Peter Palese, PhD

The Palese Laboratory focuses on fundamental questions concerning the genetic make-up and biology of viruses, as well as virus-host interactions. They use molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts. Emphasis is on the study of RNA viruses, including influenza, paramyxo, and corona viruses. Major research directions in the laboratory at the present time include: (1) by genetically changing influenza viruses via recombinant DNA techniques, they are studying viral genes and gene products to develop a universal influenza virus vaccine; (2) intracellular proteins are identified that interact with viral proteins, and the biological functions of these cellular proteins are studies; (3) attempts are made to develop broad spectrum antivirals and to identify their mechanisms of actions.

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References

  1. Manicassamy B, Medina RA, Hai R, Tsibane T, Stertz S, Nistal-Villán E, Palese P, Basler CF, García-Sastre A. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 2010 Jan 29;6(1):e1000745.
  2. Tumpey TM, García-Sastre A, Mikulasova A, Taubenberger JK, Swayne DE, Palese P, Basler CF. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13849-54.
  3. Glaser L, Stevens J, Zamarin D, Wilson IA, García-Sastre A, Tumpey TM, Basler CF, Taubenberger JK, Palese P. A single amino acid substitution in 191
  4. Hai R, Krammer F, Tan GS, Pica N, Eggink D, Maamary J, Margine I, Albrecht RA, Palese P.Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes. J Virol. 2012 May;86(10):5774-81.
  5. He W, Mullarkey CE, Duty JA, Moran TM, Palese P, Miller MS. Broadly neutralizing anti-influenza virus antibodies: enhancement of neutralizing potency in polyclonal mixtures and IgA backbones. J Virol. 2015 Apr;89(7):3610-8.
  6. Balaji Manicassamy, Rafael A. Medina, Rong Hai, Tshidi Tsibane, Silke Stertz, Estanislao Nistal-Villán, Peter Palese, Christopher F. Basler, Adolfo García-Sastre. Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines. PLoS Pathog. 2010 January; 6(1): e1000745.