Edward Perez-Reyes, PhD, University of Virginia
Edward Perez-Reyes, PhD
The major contribution of the Perez-Reyes laboratory has been on the molecular physiology and pharmacology of voltage-gated calcium channels, and in particular, the cloning of low voltage-activated T-type calcium channels. These recombinant channels were then stably expressed in HEK-293 cells, and then validated by patch clamp electrophysiology and high throughout Calcium-based assays (Xie et al. 2007). Novel T-type channel blockers have been developed that show efficacy in animal models of absence epilepsy and neuropathic pain.
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References
- Xie X, Van Deusen AL, Vitko I, Babu DA, Davies LA, Huynh N, Cheng H, Yang N,Barrett PQ, Perez-Reyes E. Validation of high throughput screening assays againstthree subtypes of Ca(v)3 T-type channels using molecular and pharmacologicapproaches. Assay Drug Dev Technol. 2007 Apr;5(2):191-203.
- Perez-Reyes, E., Van Deusen, A., Vitko, I. Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs. JPET 328:621-7, 2009.
- Gomora JC, Murbartián J, Arias JM, Lee JH, Perez-Reyes E. Cloning andexpression of the human T-type channel Ca(v)3.3: insights into prepulsefacilitation. Biophys J. 2002 Jul;83(1):229-41.
