Marianne Wessling-Resnick, PhD, Harvard University
Marianne Wessling-Resnick, PhD
Dr. Wessling-Resnick's research program centers on metal metabolism and in particular, genetic disorders of iron metabolism. Her studies have elucidated the role of iron status (both deficiency and overload) in the regulation of iron and manganese uptake by the intestinal, pulmonary and olfactory pathways. Using animal models, her work has defined the function of the iron transporters divalent metal transporter-1 (DMT1) and ferroportin (Fpn) to characterize â??iron-responsive manganese uptake.â?
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References
- Wetli HA, Buckett PD, Wessling-Resnick M. Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake. Chem Biol. 2006 Sep;13(9):965-72.
