Paul C. Leavis, PhD, Boston Biomedical Research Institute

Paul Leavis, PhD
Paul C. Leavis, PhD

Dr. Leavis is Senior Scientist at Boston Biomedical Research Institute (BBRI), Watertown, MA, where for over 35 years he has become an expert in protein characterization and in the design, synthesis, purification and characterization of peptides for research. Dr. Leavis received his Ph.D. from Tufts University in Boston where he studied the physico-chemical properties of fibrinogen. As a post-doctoral fellow at BBRI he carried out spectroscopic studies on the structure and interactions of muscle proteins and received fellowships from the Muscular Dystrophy Assocation and NATO. His later work was supported by an Established Investigator Award from the American Heart Association and from grants from NIH. Dr.Leavis runs the protein peptide core facility at BBRI and is an Associate Professor at Tufts University School of Medicine, Sackler Scool of Graduate Biomedical Sciences and the Gerald J. and Dorothy R.Friedman School of Nutrition Science and Policy at Tufts. In his current studies on leptin, he has synthesized several peptides that bind to the leptin receptor and block leptin signaling, and is currently studying the ability of these leptin antagonist peptides to inhibit growth and adhesion of breast and endometrial cancer cells.

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References

  1. Ramos, M. P., Rueda, B. R., Leavis, P. C. & Gonzalez, R. R. Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process. Endocrinology. 2005; 146, 694-701.
  2. Gonzalez RR, Rueda BR, Ramos MP, Littell RD, Glasser S, Leavis PC. Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling. Endocrinology. 2004 Aug;145(8):3850-7.
  3. Je HD, Gallant C, Leavis PC, Morgan KG. Caveolin-1 regulates contractility in differentiated vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H91-8.
  4. Gonzalez RR, Leavis PC. A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells. Endocrine. 2003 Jul;21(2):185-95.
  5. Gonzalez, R. R., Leary, K., Petrozza, J. C. & Leavis, P. C. Leptin regulation of the interleukin-1 system in human endometrial cells. Mol Hum Reprod 2003 9(3), 151-8.
  6. Barnea, E.R., Aboagye-Mathiesen, G., Hatch, W.C. & P.C. Leavis (2001) Pregnancy derived compounds that control proliferation. Cancer & Pregnancy, Barnea, E.R., Jauniaux, E., Schwartz, P.E. (eds) Springer-Verlag London.