Cristina M. Furdui, PhD, Wake Forest School of Medicine
The Furdui laboratory is interested in applying chemical, computational and advanced systems biology methodologies to investigate the molecular mechanisms linking redox balance to disease development and treatment. Specifically, the laboratory focuses on: 1] Development of Chemical Approaches for the Quantitative Analysis of Protein Thiol Oxidative Modifications; 2] The Implications of Akt2 Redox-regulation in Radiation-associated Diabetes and Muscle Function in Aging, and 3] Head and Neck Cancer Prevention, Treatment and Improvement of Quality of Life. Chemical and analytical methods developed in the context of these projects are further applied to a number of collaborative studies investigating redox effects in aging, kidney disease, inflammation, sepsis and others.
Part of The Investigator's Annexe program.
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References
- Qian, J., Wani, R., Klomsiri, C., Poole, L.B., Tsang, A.W., and Furdui, C.M. A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes. Chem. Commun., 48, 4091â??4093 (2012).
- Qian, J., Klomsiri, C., Wright, M.W., King, S.B., Tsang, A.W., Poole, L.B, and Furdui, C.M. Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chem. Commun., 47, 9203â??9205 (2011).
