The Hand laboratory employs morphological, immunological and biochemical methodology to study protein expression and localization in salivary glands. Current areas of interest are: (1) microgravity effects on structure and protein expression in salivary glands; (2) the localization of salivary proteins in human salivary glands; and (3) the expression, localization and function of cyclic AMP-binding proteins in salivary glands and saliva.