Jay C. Brown, PhD, University of Virginia
Jay C. Brown, PhD
The Brown laboratory is interested the structure and assembly of the herpes simplex virus capsid. HSV-1 is the leading cause of non-epidemic encephalitis in the U.S. In their laboratory they study the structure and assembly of the HSV-1 virion with the idea that such studies will suggest the nature of novel anti-herpes therapeutic agents directed against the assembly process.
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References
- Spencer JV, Trus BL, Booy FP, Steven AC, Newcomb WW, Brown JC. Structure of the herpes simplex virus capsid: peptide A862-H880 of the major capsid protein is displayed on the rim of the capsomer protrusions. Virology. 1997 Feb 17;228(2):229-35. PubMed PMID: 9123829.
- Newcomb WW, Homa FL, Thomsen DR, Booy FP, Trus BL, Steven AC, Spencer JV, Brown JC. Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation. J Mol Biol. 1996 Nov 1;263(3):432-46. PubMed PMID: 8918599.
