David G. Kaufman, MD, PhD, University of North Carolina at Chapel Hill
There are two areas of research in the Kaufman laboratory: 1.) One is a basic research study that is investigating a general characteristic of cancer development. It is largely a genomics study using molecular biology methodology to study DNA replication origins and regions of DNA replicated at the beginning of S phase. 2.) The second is a translational study concerned with the mechanisms of development of a specific type of cancer: endometrial cancer. They reconstruct human endometrium in culture from its constituent cells and study the interaction between endometrial epithelial and stromal cells that determine normal tissue structure and function. In this system they are attempting to reproduce the progressive steps of endometrial cancer development.
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References
- Barbier CS, Becker KA, Troester MA, Kaufman DG. Expression of exogenous human telomerase in cultures of endometrial stromal cells does not alter their hormone responsiveness. Biol Reprod. 2005 Jul;73(1):106-14. Epub 2005 Mar 16. PubMed PMID: 15772261.
- Barbier C, Kloosterboer HJ, Kaufman DG. Effects of tibolone metabolites on human endometrial cell lines in co-culture. Reprod Sci. 2008 Jan;15(1):75-82.
