Rima Rozen, PhD, McGill University
Rima Rozen, PhD
Dr. Rozen's research focuses on genetic deficiencies in the metabolism of an important vitamin, folic acid. Disturbances in the body's handling of folic acid can lead to increased risk for a wide variety of disorders including birth defects (spina bifida or heart defects), fatty liver, colorectal cancer and brain dysfunction. Her laboratory studies the mechanisms that lead to these complex traits with the aim of identification of biomarkers or novel therapeutic strategies.
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References
- Tran P, Leclerc D, Chan M, Pai A, Hiou-Tim F, Wu Q, Goyette P, Artigas C, Milos R, Rozen R. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Mamm Genome. 2002 Sep;13(9):483-92.
- Mikael LG, Rozen R. Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS. Cardiovasc Res. 2008 Oct 1;80(1):151-8. doi: 10.1093/cvr/cvn157. Epub 2008 Jun 7.
