Eishi Noguchi, PhD, Drexel University
The Noguchi Lab works with mammalian cells and fission yeast (Schizosaccharomyces pombe). Fission yeast is an exceptional model system for studying cell cycle control and genome maintenance mechanisms that are highly conserved amongst most eukaryotes, including humans. Their general approach defines principles and identifies important proteins in fission yeast and then determines whether human homologues of these proteins have related function using mammalian cell culture. Their current research projects include: 1) Identify and investigate the mechanisms of DNA replication at difficult-to-replicate chromosomal regions. 2) Investigate the mechanisms of alcohol-mediated genomic instability and esophageal carcinogenesis. 3) Investigate the genetic mechanisms that govern lifespan extension by preserving genomic integrity.
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References
- Gadaleta MC, Iwasaki O, Noguchi C, Noma K, Noguchi E. New vectors for epitope tagging and gene disruption in Schizosaccharomyces pombe. Biotechniques. 2013 Nov;55(5):257-63.
