Jochen Walter, PhD, University of Bonn

Jochen Walter, PhD
Jochen Walter, PhD

Dr. Walter's laboratory research is focused on the functional role of genetic factors, in particular the amyloid β peptide, in the initiation and progression of neurodegeneration. The overall aim of their research is to identify pathways and molecular targets for future therapy and diagnosis.

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References

  1. Kumar S, Wirths O, Theil S, Gerth, J, Bayer TA, Walter J. Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease. Acta Neuropathol 2013; 125: 699-709.
  2. Rijal Upadhaya A, Scheibe F, Kosterin l, Abramowski D, Gerth J, Kumar S, Liebau S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR.The type of AÃ?-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid Ã?peptide (APP48) transgenic mice. Acta Neuropathol Commun. 2013; 1:77.
  3. Rijal Upadhaya A, Kosterin l, Kumar S, von Arnim CA, Yamaguchi H, Fändrich M, Walter J, Thal DR. Biochemical stages of amyloid-� peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. Brain. 2014; 137(Pt 3):887-903.
  4. Balakrishnan K, Rijal Upadhaya A, Steinmetz J, Reichwald J, Abramowski D, Fändrich M, Kumar S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR. Impact of amyloid � aggregate maturation on antibody treatment in APP23 mice. Acta Neuropathol Commun. 2015; 3:41.