Bernhard B. Singer, PhD, University of Duisburg-Essen

Bernhard B. Singer, PhD
Bernhard B. Singer, PhD

The Singer laboratory research is focused on the role of CEACAMs in infection, inflammation and wound healing. Specifically, they are looking at CEACAM (CD66) function in leukocytes, epithelia, endothelia, extracellular microvesicles, and as pathogen receptor (bacterial binding). They are also involved in the development of novel CEACAM mouse monoclonals and Fc proteins.

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References

  1. Singer BB, et al. (2014) Soluble CEACAM8 interacts with CEACAMl inhibiting TLR2-triggered immune responses.
  2. PLoS ONE9(4):e94106 Seifert et al. (2015) Functional capacities of human lgM memory B cells in early inflammatory responses andvsecondary germinal center reactions. Proceedings of the National Academy of Sciences 112(6):546-555.
  3. Ullrich et al. (2015) CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival. Cancer Res. May 1;75(9):1897-907.
  4. Khairnar et al. (2015) CEACAMl induces B-ce!I survival and is essential for protective antiviral antibody production. Nat Commun. 18;6:6217.
  5. Javaheri et al. (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2:16189.
  6. Mach et al. (2017) Soluble CEACAMl and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy. Am J Reprod lmmunol. 2017 Oct;78(4). doi: 10.1111/aji.12700.
  7. Khairnar et al. (2018} CEACAM 1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 9(1):2561.