Carlos T. Moraes, PhD, University of Miami

Carlos T. Moraes, PhD
Carlos T. Moraes, PhD

The Moraes laboratory works on the molecular basis of mitochondrial disorders which are caused by defects in the cellular energy production system. Mitochondria contain their own DNA (mtDNA) and mutations in either mtDNA or nuclear DNA can disrupt the ATP synthesis machinery and trigger a number of pathways that can lead to disease. Besides studying the function of mitochondrial proteins affecting energy production, they also study the role of mitochondrial function in aging and develop pharmacological and genetic approaches to treat mitochondrial diseases.

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References

  1. Diaz F, Fukui H, Garcia S, Moraes CT. Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts. Mol Cell Biol. 2006 Jul;26(13):4872-81. PubMed PMID: 16782876; PubMed Central PMCID: PMC1489173.
  2. Diaz F, Enríquez JA, Moraes CT. Cells lacking Rieske iron-sulfur protein have a reactive oxygen species-associated decrease in respiratory complexes I and IV. Mol Cell Biol. 2012 Jan;32(2):415-29. doi: 10.1128/MCB.06051-11. Epub 2011 Nov 21. PubMed PMID: 22106410; PubMed Central PMCID: PMC3255782.
  3. Vempati UD, Han X, Moraes CT. Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV. J Biol Chem. 2009 Feb 13;284(7):4383-91. doi: 10.1074/jbc.M805972200. Epub 2008 Dec 15. PubMed PMID: 19075019; PubMed Central PMCID: PMC2640958.
  4. Vempati UD, Diaz F, Barrientos A, Narisawa S, Mian AM, Millán JL, Boise LH, Moraes CT. Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release. Mol Cell Biol. 2007 Mar;27(5):1771-83. Epub 2007 Jan 8. PubMed PMID: 17210651; PubMed Central PMCID: PMC1820455.