David W. Essex, MD, Temple University
David W. Essex, MD
The Essex laboratory overall goal is to examine the role of reactions involving thiols and disulfides, and protein disulfide isomerase in hemostasis, atherosclerosis and wound healing. More specifically, to define the role of thiol-disulfide reactions and platelet protein disulfide isomerases in integrin activation and platelet function. A related project is to characterize a transmembrane electron transport system on the platelet surface that reduces disulfide bonds in platelet surface proteins. A final goal is to characterize oxidative modifications of thiols in conditions associated with oxidative stress.
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References
- Wu Y, Ahmad SS, Zhou J, Wang L, Cully MP, Essex DW. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis. Blood. 2012 Feb 16;119(7):1737-46.
