Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] Antibody
![Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/917_200120200126279160.jpg "Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] Antibody")
This IgG1 mouse monoclonal (AP3) was generated against human platelets and is specific for PSI/Hybrid (amino acids 50-62) of human glycoprotein IIIa (GPIIIa; CD61).
Highlights:
- Reacts with human glycoprotein IIIa
- Suitable for non reduced Western Blot, Flow Cytometry, ELISA and Affinity Chromatography
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
This IgG1 mouse monoclonal (AP3) was generated against human platelets and is specific for PSI/Hybrid (amino acids 50-62) of human glycoprotein IIIa (GPIIIa; CD61).
Highlights:
- Reacts with human glycoprotein IIIa
- Suitable for non reduced Western Blot, Flow Cytometry, ELISA and Affinity Chromatography
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
Specifications
| Product Type: | Antibody |
| Antigen: | Glycoprotein IIIa |
| Accession ID: | P05106 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | AP3 |
| Reactivity: | Human |
| Immunogen: | Human platelet |
| Species Immunized: | Mouse |
| Epitope: | PSI/Hybrid (amino acids 50-62) |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium azide |
| Tested Applications: | Flow Cytometry (0.02 mg/mL), ELISA capture (10ug/mL) and detection (10ug/mL) |
| Storage: | -20C |
| Shipped: | Cold packs |
Research
| Antibody | Domain |
| Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
| Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
- Pidard D, Montgomery RR, Bennett JS, Kunicki TJ. Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J Biol Chem. 1983 Oct 25;258(20):12582-6.
- Peterson JA, Nelson TN, Kanack AJ, Aster RH. Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA. Blood. 2008 Feb 1;111(3):1234-9. Epub 2007 Oct 24.
- Ruiz C, Liu CY, Sun QH, Sigaud-Fiks M, Fressinaud E, Muller JY, Nurden P, Nurden AT, Newman PJ, Valentin N. A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype. Blood. 2001 Oct 15;98(8):2432-41.
- Honda S, Tomiyama Y, Pelletier AJ, Annis D, Honda Y, Orchekowski R, Ruggeri Z, Kunicki TJ. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit. J Biol Chem. 1995 May 19;270(20):11947-54.
- Faralli JA, Dimeo KD, Trane RM, Peters D. Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone. PLoS One. 2018 Mar 2;13(3):e0192665. View Article
- Faralli JA, Filla MS, Peters DM. Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1776-1788. View Article
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