Anti-Complement C3a/C3a (desArg)/C3 [K5/9] Antibody
![Anti-Complement C3a/C3a (desArg)/C3 [K5/9] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1221_2001202001263912200.jpg "Anti-Complement C3a/C3a (desArg)/C3 [K5/9] Antibody")
This mouse IgG1k monoclonal antibody was generated against purified porcine complement C3a and recognizes porcine complement C3a/C3a (desArg).
Highlights:
- Specific for porcine C3a/C3a (desArg)
- Useful as detecting antibody in C3a ELISA
- Blocks C3a biological activity
- Suitable for Western Blot and ELISA applications, as well as functional studies
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.
From the laboratory of Martin Oppermann, MD, University Medical Center Göttingen.
This mouse IgG1k monoclonal antibody was generated against purified porcine complement C3a and recognizes porcine complement C3a/C3a (desArg).
Highlights:
- Specific for porcine C3a/C3a (desArg)
- Useful as detecting antibody in C3a ELISA
- Blocks C3a biological activity
- Suitable for Western Blot and ELISA applications, as well as functional studies
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.
From the laboratory of Martin Oppermann, MD, University Medical Center Göttingen.
| Product Type: | Antibody |
| Antigen: | Porcine C3a/C3a (desArg) |
| Accession ID: | Q16581 |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Clone Name: | K5/9 |
| Reactivity: | Porcine |
| Immunogen: | Purified porcine C3a |
| Species Immunized: | Mouse (Balb/c) |
| Epitope: | N/A |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA, and Functional Studies |
| Storage: | -20C |
| Shipped: | Cold packs |
| Clone | Reactivity | Isotype | Epitope | Applications | Functional Properties |
| M20/6 | Human Ba / Factor B | IgG1k | N/A | WB, ELISA, IP | Detecting Ab in Ba ELISA (together with D22/3) |
| D22/3 | Human Ba | IgG2b/k | Neo-Epitope on Ba (Glu215, Arg234) | WB, ELISA, Flow Cytometry | Capture Ab in Ba ELISA (together with M20/6) |
| I3/15 | Human and baboon activated C3 | IgG1k | Neo-Epitope on C3b/iC3b/C3dg | WB, ELISA | Capture Ab in actC3 ELISA (together with rab anti-C3dg) |
| Z22/8 | Porcine C3a/C3a(desArg) | IgG2b/k | Neo-Epitope on C3a/C3a(desArg) | WB, ELISA, IP | Capture Ab in C3a ELISA (together with K5/9); blocks C3a biological activity |
| K5/9 | Porcine C3a/C3a(desArg) | IgG1k | N/A | WB, ELISA | Capture Ab in C3a ELISA (together with Z22/8); blocks C3a biological activity |
| G25/2 | Human and baboon C5/C5a/C5a(desArg) | IgG1k | N/A | WB, ELISA, IP | Detecting Ab in C5a ELISA (together with C17/5); blocks C5a biological activity |
| C17/5 | Human and baboon C5/C5a/C5a(desArg) | IgG1k | Neo-Epitope on C5a/C5a(desArg) | WB, ELISA | Capture Ab in C5a ELISA (together with G25/2); blocks C5a biological activity |
| T13/9 | Porcine C5a/C5a(desArg) | IgG1k | Neo-Epitope on C5a (Tyr57- Gly74) | WB, ELISA, IP | Capture Ab in C5a ELISA (together with rab anti-C5a); blocks C5a biological activity |
- Oppermann, M., Höpken, U., and Götze, O. (1992) Immunopharm. 24, 119-134
- Höpken, U., Strüber, A., Oppermann, M., Mohr, M., Mücke, K. H., Burchardi, H., and Götze, O. (1993) Production and characterization of peptide-specific monoclonal antibodies that recognize a neoepitope on hog C5a. In Faist, E., Meakins, J., and Schildberg, F. W., editors. Host defense dysfunction in trauma, shock and sepsis, Berlin,Heidelberg, Springer Verlag.
- Höpken, U., Mohr, M., Struber, A., Montz, H., Burchardi, H., Götze, O., and Oppermann, M. (1996) Eur. J. Immunol. 26, 1103-1109
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