This rabbit IgG polyclonal antibody was generated against the GST-ADAM12-cytoplasmic tail and is specific for the cytoplasmic domain of mouse ADAM12.
The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).
Like the other ADAM members, ADAM12 is structurally related to snake venom disintegrins. It has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. ADAM12 has been implicated in breast and prostate cancer.
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
Part of The Investigator's Annexe program.
Product Type: | Antibody |
Antigen: | GST-ADAM12 cytoplasmic domain |
Accession ID: | O43184 |
Isotype: | IgG |
Clonality: | Polyclonal |
Reactivity: | Mouse |
Immunogen: | GST-cyto corresponding to the cytoplasmic domain of mouse ADAM12 |
Species Immunized: | Rabbit |
Epitope: | Cytoplasmic domain |
Purification Method: | Serum, not purified |
Tested Applications: | WB (1:500) |
Storage: | -80C |
Shipped: | Dry ice |
Antibody | Species Reactivity | Specificity |
ADAM9 | Human | Cytoplasmic Domain |
ADAM9 | Mouse | Cytoplasmic Domain |
ADAM12 | Mouse | Cytoplasmic Domain |
ADAM15 | Human | Cytoplasmic Domain |
ADAM15 | Mouse | Cytoplasmic Domain |
ADAM15 | Human | Extracellular Domain |
ADAM15 | Mouse | Disintegrin Domain |
ADAM17 | Mouse | Cytoplasmic Domain |
ADAM17 | Mouse | Pro domain |
ADAM19 | Mouse | Cytoplasmic Domain |
ADAM28 | Mouse | Cytoplasmic Domain |
ADAM28 | Mouse | Extracellular Domain |
SNX9 | Mouse | Cytoplasmic Domain |
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